ABSTRACT
Hypertensive disorder of pregnancy affecting multiple systems and woman has dangerously high blood pressure, swelling, and protein in the urine. Therefore serum albumin and uric acid are useful biochemical markers reflecting the severity of the occurrence of preeclampsia and eclampsia. Objective: The aim was to study the role of albumin and uric acid in preeclampsia and eclampsia. Methods: This is the case-control hospital based study carried in the Grant Government Medical College and Sir J.J. Group of Government Hospitals, Mumbai. Normotensive pregnant women (n=50) and women with preeclampsia (n=50) and eclampsia (n=50) were included in the study. Both the groups were in their third trimester and of same age and same gestational age. Serum albumin and uric acid were estimated by BCG endpoint and Uricase – PAP method respectively. Result: The alterations of serum albumin and uric acid levels in preeclampsia and eclampsia pregnant subjects were found as compared to those of control group. A negative and significant correlation (r = -0.492 and -0.602, p < 0.001) was observed between serum albumin with uric acid in study subjects. Conclusion: The results suggest that, albumin and uric acid are important factors in the pathogenesis of preeclampsia and eclampsia and are directly related to the severity of disease.
ABSTRACT
The objective of the study was to find out the factors predicting outcome of trial of labour after previous caesarean delivery among women living in a developing country. A retrospective study of 149 cases of trial of Labour was conducted in women with a history of one prior caesarean section. Binary logistic regression was used to identify predictive factors. The adjusted odds ratios with 95% confidence intervals (95%CI) were used to indicate risk of failure of the trial of Labour when the factor was present. It was found that success rate of vaginal birth was 24.16%. Factors significantly predictive of success of trial of Labour were previous vaginal delivery (OR 18.4, 3.3 -329.6), baby weight < 3 kg (OR 33.3, 5.4-62.6) and 2nd stage of labour during previous LSCS (OR 2.1, 1-4.2). The study has shown that trial of labour can be attempted successfully, in women with previous caesarean delivery, with due consideration of maternal and foetal outcome. A prior history of vaginal delivery and baby weight < 3 kgs are the best predictor of success of trial of labour.